Research in Dr. Skaggs’ lab examines repair and regeneration following brain damage using adult Zebrafish as a model system. Brain damage is one of the most devastating of human injuries, resulting in lifelong disability largely due to the inability of the human central nervous system to repair or regenerate damaged neurons. Unlike mammals, neural progenitor cells in the adult Zebrafish brain proliferate in response to injury, migrate to the site of injury and appear to integrate into existing circuitry to restore brain tissue. Zebrafish are vertebrates that share many developmental and functional features with mammals, so understanding mechanisms of successful brain regeneration in Zebrafish may suggest approaches for augmenting repair and recovery after brain damage, disease, and degeneration in humans. Current research projects involve the role of neuroinflammation in stimulating regeneration and other mechanisms of neuronal regeneration and repair, alternative brain injury models, and characterization of individual cellular responses to damage.