Faculty & Staff

Alexander Vaglenov, M.D., Ph.D.
Alexander Vaglenov, M.D., Ph.D.
Associate Professor of Pharmaceutical Sciences
Year started at UF: 2007
Contact Information
Office Location: 300 Davis Street 109
Telephone: 419-434-5388
Credentials
M.D., Kharkov Medical University
D.P.M.S., Kharkov Medical University
  • Academic Credentials:

    Doctor of Medicine, Kharkov Medical Institute, Public Health
    Doctor of Philosophy in Medical Sciences


    Dr. Alexander Vaglenov, earned a M.D. degree from the Kharkov Medical University in the former Soviet Union, and later obtained a Ph.D. degree in Medicine and Radiobiology from the Bulgarian Medical Academy in Sofia. He previously served in the Military Medical Academy’s Hospital in Sofia, Bulgaria as a microbiologist. After that he obtained a faculty position in the Bulgarian National Centre of Radiobiology and Radiation Protection in Sofia. From 1975 till 1989 he did investigations on space flight experiments carried out in the frame of research program of Moscow Institute for Biomedical Problems (former USSR). At the same time he was involved in the research on biological effects from Heavy Charged Particles with assessment of the health risk for astronauts.

    In 1988-89 he was awarded from the International Atomic Energy Agency (IAEA) with a post-doctoral fellowship for training in the Department of Radiation and Chemical Mutagenesis at the University of Leiden, The Netherlands. In 1996 the Spanish Ministry of Education and Science granted him one and a half years as a visiting professor at the Department of Genetics and Microbiology of the Autonomous University of Barcelona, Spain.

    In 1999 he received a second award from IAEA for a scientific visit in the Department of Radiobiology of the Radiation Effects Research Foundation in Hiroshima, Japan. Meanwhile from 1999-2001 he joined Bulgarian National Centre of Radiobiology and Radiation Protection as Associate Professor. In September 2001 he joined the Department of Pathobiology, College of Veterinary Medicine at Auburn University (AL) and in 2007 joined the School of Pharmacy at The University of Findlay.

    Dr. Vaglenov was the recipient of several national and international grants, author and co-author of over 70 peer reviewed publications and 50 international presentations.
  • Professional Organizations:
    • Radiation Research Society (RRS) U.S.A.
    • Chlamydia Basic Research Society (CBRS) U.S.A.
    • Environmental Mutagen Society (EMS) U.S.A.
    • International Association of Environmental Mutagen Societies (IAEMS).
    • Federation of American Society of Experimental Biology (FASEB)

    Research Interests:
    • Cancer biology, mechanisms of cancer development and experimental therapeutics.
    • Radiosensitivity and repair processes in cancer patients and healthy persons DNA.
    • Epidemiology of occupational cancer. Antimutagenic/anticarcinogenic treatment and prophylaxes of environmentally or occupationally exposed groups to ionizing radiation and chemical carcinogens; stem cells technology and gene therapy.
    • Marketed and new drugs genotoxicity/cancerogenicity evaluation.
    • Population Genetics: Germ and somatic cells spontaneous mutations. Nutrigenomics and genome stability.
    • Occupational medicine. Biomarkers for environmental and occupational exposure to chemical and physical agents. Pharmacological prophylaxes of occupationally exposed groups.
    • Genetic control of susceptibility to ionizing radiation: definition of molecular targets for radioprotective strategies (pharmacy-therapy) and gene therapy. Computational analysis based on susceptibility of inbred mouse strains to ionizing radiation as an alternative method to the classical QTL analysis.
    • Biological effects of High and Low LET ionizing radiations:
    • Genetic effects of Low LET radiation with assessment of the risk. Factors responsible for somatic and germ cells susceptibility and their interaction.
    • Space Biology and Medicine. Space flight factors influence on hereditary structures of somatic and germ cells. RBE of heavy charged particles and neutrons. Dose-rate effect and radioprotective (on a base of pharmaceuticals) strategies in interplanetary space missions. Cancer risk assessment.
    • Microbiology, Epidemiology of Infectious diseases, Bioterrorism.
  • Selected Peer Reviewed Publications:

    • Matthew O. Vallejo, Glenn P. Niemeyer, Alex Vaglenov, Tommy Hock, Bridget Urie, Peter Christopherson, and Clinton D. Lothrop Jr. Decreased hematopoietic progenitor cell mobilization in pearl mice. Experimental Hematology, 41, 2013, 848-857.
    • Fedorenko B, A. Vaglenov, A. N. Abrosimova Cytological and Cytogenetic Damages of Spermatogonial Cells in Mice in the Acute and Late Periods after Irradiation by Protons, Helium Ions, and γ Rays, Radiation Biology and Ecology, 50 (2), 2010, 153-158. (in russian)
    • G.Min-Oo, L. Lundquist, A. Vaglenov, C. Wang, F. Fortin, Y. Li, B. Kaltenboeck, P. Gros. Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse. Genes and Immunity, 2008, 9, 383-388.
    • Vaglenov A., Fedorenko B., Kaltenboeck B. Genetic effectiveness of protons, heavy charged particles and 1.5 MeV neutrons. Adv Space Res, 39, 2007, 1093-1101.
    • Wang C., Kim T., Gao D., Vaglenov A., Kaltenboeck B. Rapid high-yield mRNA extraction for reverse-transcription PCR. J. Biochem Biophys Methods, 70, 2007, 507-509.
    • Li D., Borovkov A., Vaglenov A., Wang C, Kim T., Gao D, Sykes K., Kaltenboeck B. Mouse model of respiratory Chlamydia pneumoniae infection for a genomic screen of subunit vaccine candidates. Vaccine, 24 (15), 2006, 2917-2927.
    • Kaltenboeck B, H. Hehnen, A. Vaglenov Bovine Chlamydophila spp. Infection: Do we underestimate the impact on fertility? Veterinary Research Communications, 29 (Suppl.1), 2005, 1-15.
    • Dan Li, A. Vaglenov, T. Kim, C. Wang, B. Kaltenboeck. High-yield culture and purification of Chlamydiaceae bacteria. Journal of Microbiological Methods, 61, 2005, 17-24.
    • Wang C., Gao D., Vaglenov A., Caltenboeck B. One-step duplex reverse transcriptase PCRs simultaneously quantify analyze and Housekeeping gene mRNAs. Biotechiques, March, 36 (3)2004, 508-519.
    • Pitarque M., A. Vaglenov, M. Nosko, S. Pavlova, V. Petkova, A. Hirvonen, H. Norppa, A. Creus, R. Marcos. The application of SCE and MN assay in the biomonitoring of solvent exposed shoe workers. Environ. Health Perspectives 110, 4, 2002, 399-404.
    • Vaglenov A., A. Creus, S. Lalchev, V. Petkova, S. Pavlova, A. Creus, R. Marcos. Occupational exposure to lead and genetic damage induction. Environ. Health Perspectives, 109, 3, 2001, 295-298.
    • Vaglenov A., M. Nosko, R. Georgieva, E. Carbonell, A. Creus, R. Marcos. Genotoxicity and radioresistance in electroplating workers exposed to chromium. Mutation Res., 446, 1999, 23-34.
    • Pitarque M., A. Vaglenov, M. Nosko, A. Hirvonen, H. Norppa, A. Creus, R. Marcos. Evaluation of DNA damage by Comet assay in the shoe workers exposed to toluene and other organic solvents. Mutation Res., 441, 1999, 115-127.
    • Vaglenov A., E. Carbonell. Radiosensitivity of Young and Adult subjects. Centr Europ. J. of Occupat. And Environ. Medicine, 4(4), 1998, 361-371.
    • Vaglenov A., E. Carbonell, R. Marcos. Biomonitoring of workers exposed to lead. Genotoxic effects, its modulation by polyvitamin treatment and evaluation of the induced radioresistance. Mutation Res., 1998, 79-92.
    • Vaglenov A., V. Petkova, S. Lalchev et al., Cytogenetic monitoring of workers exposed to lead. Centr. Europ. J. of Occupat. Environ. Medicine, 3(4), 1997, 298-308.
    • Vaglenov A., A. Karadjov. Micronucleus frequencies in Bulgarian control populations. Centr. Europ. J. of Occupat. Environ. Medicine, 3(3), 1997, 187-194.
    • Vaglenov A., E. Yaneva, S. Lalchev et al. Antimutagenetic prophylaxis of occupational risks groups. Centr. Europ.J. of Occupat. Environ. Medicine, 3(2), 1997, 114-124.
    • Vaglenov A., V. Bliznakov, A. Karadjov. Cytogenetic monitoring of workers from a nuclear power plant. Centr.Europ.J. of Occupat. Environ. Medicine, 3(1), 1997, 40-47.
  • Honors:

    Invited Lecturer:

    Department of Genetics and Microbiology, Autonomous University of Barcelona, Spain.

    • "Biomonitoring of human populations exposed to heavy metals with special attention on the aging processes on cytogenetic endpoints", May 1997.
    • "Biomonitoring of human populations exposed to organic solvents", September 1998.
    • "Antimutagenic/anticarcinogenic prophylaxis of occupationally exposed groups", May 1999.

    Department of Radiobiology of the Radiation Effects Research Foundation, Hiroshima, Japan, September 1999.

    • "Cytogenetic monitoring of groups exposed to ionizing irradiation. Adaptive response"
    • "Biomonitoring of environmentally exposed to tobacco and alcohol populations. Role of antioxidant treatment to increase their radioresistance".

    Awards:

    • Award from International Atomic Energy Agency (IAEA) for outstanding researcher. Three months training in the Lab of Radiation and Chemical Mutagenesis in Leiden University, Leiden, The Netherlands, 11/01/1988-1/01/1989.
    • Grant award from Spanish Ministry of Education and Culture for one and half Sabbatical year in the Autonomous University of Barcelona, Spain, 1997-1999.
    • Award from International Atomic Energy Agency (IAEA) for 21 days scientific visit in The Radiation Effects Research Foundation, Hiroshima, Japan, September-October 1999.

    Selected Presentations from International Meetings:

    • Goodman M, Comshaw-Arnold D, Vasquez M, Kutsar V, Dudley R, Vaglenov A. In vitro mutagenic and genotoxic potential of artemisinin, artesunate and artemether. Environ Mol Mutagenesis, 2015, 56, S1, P75, pp S76.
    • Kutsar V, LaFollette S, Gothke S, Wanner J, Vaglenov A. Genotoxic potential of omeprazole on human peripheral blood lymphocytes. Environ Mol Mutagenesis, 2014, 55, S1, P7, pp 41.
    • Kutsar V, LaFollette S, Vasquez M, Edelbrock M, Walker D, Vaglenov A. Genotoxic activity of three fungi extracts. Environ Mol Mutagenesis, 2014, 55, S1, P8, pp 41.
    • LaFollette S, Kutsar V, Gothke S, Vaglenov A. Investigation on genotoxic effects of olanzapine. Environ Mol Mutagenesis, 2014, 55, S1, P9, pp 41.
    • S. Gothke, V. Kutsar, S. LaFollette, Dudley R, A. Vaglenov. Genotoxic effects of NSAID's. 44 Annual Meeting of EMS 21-25 September 2013, Monterey, CA, Environ Mol Mutagenesis, 2013, 54, (S1), LB7..
    • B. Schumacher, S. Gothke, R. Dudley, A. Vaglenov. Single and combine genotoxic effects of celecoxib and bleomycin. 43rd Annual Meeting of EMS 2012, 8-12 September 2012, Bellevue, Washington, Environ Mol Mutagenesis, 2012, 53 (S1), 55.
    • Ashley Kasper, Samuel Gothke, Richard Dudley, Alexander Vaglenov. Genotoxic effect of antihypertensive drug Atenolol. 42nd Annual Meeting of EMS 2011, Hilton Bonaventure, Montreal, Quebec, Canada, October 15-19, 2011, Environ Mol Mutagenesis, 2011, 52, (S1), P127.
    • Samuel Gothke, Richard Dudley, Alexander Vaglenov. Genotoxic Evaluation of Acylated Cyclic Peptide Fragment III from Cobra Cardiotoxins on Human Lymphocytes Trough CBMN Cytome and Comet Assays. 42nd Annual Meeting of EMS 2011, Hilton Bonaventure, Montreal, Quebec, Canada, October 15-19, 2011, Environ Mol Mutagenesis, 2011, 52, (S1), P66.
    • S. Gothke, R. Dudley, A. Vaglenov. In vitro experimental approach for modulation of human lymphocytes susceptibility to cadmium by antioxidants.  41th Annual Meeting of Environmental Mutagen Society, Fort Worth, Texas, October 23-27, 2010, Environ Mol Mutagenesis, 2010, 51(7):721.
    • A.Vaglenov, R. Dudley, S. Gothke, V. Petkova. The protective effect of Centrum against genotoxicity of cadmium, lead zinc and H2SO4 exposed smelters. 41th Annual Meeting of Environmental Mutagen Society, Fort Worth, Texas, October 23-27, 2010, Environ Mol Mutagenesis, 2010, 51(7):721.
    • A. Vaglenov, B. Shinn, R. Dudley, J. Crea, J. Vaglenova, S. Lalchev, V. Petkova, K. Doneva, A.Simonian. Genotoxic Exposure Assessment in Tannery Workers with Evaluation of Antimutagenic Properties of Centrum. Poster at Xth International Meeting of Environmental Mutagen Society, 20-25 August, Florence, Italy (2009), Book of Abstracts, pp. 152.
    • A. Vaglenov, J. Crea, B. Shinn, R. DNA Damage Prevention from Vinyl Chloride Monomer (VCM) Occupational Exposure. Poster at Xth International Meeting of Environmental Mutagen Society, 20-25 August, Florence, Italy (2009), Book of Abstracts, pp.143-144.
    • A. Vaglenov, D. Parker, L. Ernsthausen, R. Marcos, A. Creus, A. Simonian. The Adaptive Response in Different Groups Occupationally Exposed to Ionizing Radiation and Chemicals. Platform Presentation at the 39th Annual Meeting of the Environmental Mutagen Society, Puerto Rico, Environ Mol Mutagenesis, 2008, 49 (7), 547.
    • A. Vaglenov, B. Shinn, M. Edelbrock, T. Schwaner, A. Simonian. The Role of Dietary Micro-Nutrient Supplementation to Maintain Genomic Stability. Poster at the 39th Annual Meeting of the Environmental Mutagen Society, Puerto Rico, Environ Mol Mutagenesis, 2008. 49 (7), 563.
    • Vaglenov A., Kaltenboeck B., Brawner W. et al. Genetic dissection of susceptibility/resistance to ionizing radiation by use of Recombinant Congenic Strain Mice. 38th Annual Meeting of Environmental Mutagen Society, October 20-24, 2007, Atlanta, Georgia, Environ Mol Mutagenesis, 2007, 48, 7, 587.
    • Vaglenov A., Lalchev S., Marcos R. et al. Genomic instability in show workers modulated by polyvitamin-polymineral treatment. Evaluation of therapeutic effect after 4 months 2 tablets daily intake of Centrum® using pancentromeric FISH. 38th Annual Meeting of Environmental Mutagen Society, October 20-24, 2007, Atlanta, Georgia, Environ Mol Mutagenesis, 2007, 48, 7, 623.

    Selected Presentations from Local Meetings:

    • K. Kovach, H. Robison, P. Hoffman, M. Goodman, D. Comshaw-Arnold. Antimutagenic and anticarcinogenic effects of epigallocatechin-3-gallate (EGCG), Undergrad poster presented at UF 9th Annual Symposium for Scholarship and Creativity, April 1, 2016, Abstracts p.40, Sponsors: A. Vaglenov, R. Dudley
    • D. Komshaw-Arnold, M. Goodman. In vitro genotoxic effect of two new chalcone flavonoids, Undergrad poster presented at UF 9th Annual Symposium for Scholarship and Creativity, April 1, 2016, Abstracts, p. 37. Sponsors: A. Vaglenov, R. Khupse, R. Dudley.
    • M. Vasquez, S. Gothke. In vitro evaluation on possible genotoxic effects of Loperamide. Undergrad presentation at Capitol, April 9, 2013, Columbus, OH, Book of Abstracts, p. 58, Sponsor: A. Vaglenov.
    • A. Kasper, S. Gothke. Genotoxic effect of antihypertensive drug Atenolol on human lymphocytes evaluated through CBMN, neutral and alkaline comet assays. Undergrad presentation at Capitol, March 27, 2012, Columbus, OH, Book of Abstracts, p. 59, Sponsors: A. Vaglenov, R. Dudley.
    • J. Pham, S. Gothke. In vitro modulation of human lymphocytes genotoxic susceptibility to Warfarin by antioxidants, Graduate posters presented at UF 5th Annual Symposium for Scholarship and Creativity, April 13, 2011, Abstracts, p. 31, 2011. Sponsors: A.Vaglenov, R. Dudley.
    • T. Phu, S. Gothke. Single and combine genotoxic effects of Amiodarone and Mitomycin-C on human lymphocytes, Graduate posters presented at UF 5th Annual Symposium for Scholarship and Creativity, April 13, 2011, Abstracts, p. 30, 2011. Sponsors: A. Vaglenov, R. Dudley.
    • A. Smith. In vitro investigation on possible genotoxic effects of Naproxen on human lymphocytes, Undergrad posters presented at UF 5th Annual Symposium for Scholarship and Creativity, April, 13, 2011, Abstracts, p. 29, 2011. Sponsors: A.Vaglenov, R. Dudley.
    • S. Gothke, S. Kusi. Are peptide fragmentys from cobra cardiotoxin genotoxic to human lymphocytes? Undergrad posters presented at UF 5th Annual Symposium for Scholarship and Creativity, April, 13, 2011, Abstracts, p. 31, 2011. Sponsors: A. Vaglenov, R. Dudley.
    • S. Gothke, A. Ghose, P. Balar. Genotoxicity of Diclofenac to human lymphocytes. Ohio Foundation for Independent Colleges (OFIC) 2011 Inaugural Undergraduate Research Symposium, February 16, 2011, Columbus, OH. Sponsors: A. Vaglenov, R. Dudley.
    • Fesko, A. James, S. Gothke. Comparing the genotoxic effects of amiodarone and mitomycine C (MMC), Abstracts, p. 28, 2010. Undergrad posters presented at UF 4th Annual Symposium for Scholarship and Creativity, April 13, 2010. Sponsors: A. Vaglenov, R. Dudley.
    • Sheena Burwell. Comparative genotoxic effects of ibuprofen, Abstracts, p.39. Undergrad presentations at Capitol, April 15, 2010, Columbus, OH. Sponsors: A. Vaglenov, R. Dudley.
    • Fesko A., S. Gothke, J.M.Guley, A. Orlando, K. Bevan, I. Popkowski. Biomarkers for Cancer Risk Evaluation in Human and Animal Lymphocytes. Supervisors: Dr. A. Vaglenov, Dr. M. Edelbrock, Dr. R. Dudley, Dr. J. Vaglenova. Poster at DNA Days of University of Findlay, Findlay, OH, (2009).